UW HSIP- Subsequent HepB Initial Dose #2

2 min. readlast update: 10.22.2025

You have submitted one HepB vaccine dose. Your next step is to complete a second HepB vaccine dose in your initial HepB vaccine series and submit the record for approval.

Make sure to follow the Hepatitis B vaccine dosing schedule for the vaccine type you are receiving if completing your initial Hepatitis B vaccine series:

· Heplisav-B (2-dose series): Dose #2 given 1 month after dose #1

· Engerix-B or Recombivax HB (3-dose series): Doses are given at respectively 0, 1, and 6 months (minimum dosing intervals are acceptable: dose #1 to dose #2: 4 weeks / dose #2 to dose #3: 8 weeks / dose #1 to dose #3: 16 weeks)

· Hepatitis AB (Twinrix) (3-dose series): Doses are given at respectively 0, 1, and 6 months (minimum dosing interval of 5 months between dose #2 and dose #3)

· Hepatitis AB (Twinrix) (4-dose series): Doses are given at respectively 0, 1 week, 21-30 days, and 12 months. However, students who choose this option should remember that 1 month after the last dose, you will still need to receive the titer to prove immunity.

If you have submitted a single HepB dose that was completed more than a year ago, then you do NOT need to restart the HepB vaccine series. When a HepB vaccine series is interrupted, you will need to continue from where you left off in the series. HSIP highly recommends switching to the 2-dose Heplisav-B vaccine series which can be completed in 1 month. If this is the case, you will need to complete both Heplisav-B doses to complete your series.

Please complete a HepB dose #2 as soon as possible and submit the record for approval.

· If you complete an Engerix-B or Recombivax HB HepB vaccine for your HepB dose #2, then you will need to complete a HepB dose #3 that is at least 8 weeks apart to complete your HepB vaccine series.

· If you completed a Hepatitis AB (Twinrix) HepB vaccine for your HepB dose #2, then you will need to complete a HepB dose #3 that is at least 5 months apart to complete your HepB vaccine series.

If you have questions, please contact HSIP at myshots@uw.edu.

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